Treatment of Retinoblastoma in 2015: Agreement and Disagreement

JAMA Ophthalmol. 2015 Nov;133(11):1341-7. doi: 10.1001/jamaophthalmol.2015.3108.


The management of intraocular retinoblastoma is rapidly changing, and even recent reviews on the subject are behind existing practices. The 4 authors of this report collectively represent their management strategies with an emphasis on areas of agreement and disagreement. Ophthalmic artery chemosurgery and intravitreous chemotherapy have completely replaced external beam radiotherapy, reduced the use of systemic chemotherapy, and diminished enucleations by 90% without evidence of compromising patient survival.

Publication types

  • Multicenter Study
  • Review

MeSH terms

  • Antineoplastic Agents / administration & dosage
  • Brachytherapy
  • Cryotherapy
  • Eye Enucleation
  • Humans
  • Infusions, Intra-Arterial
  • Intravitreal Injections
  • Laser Coagulation
  • Ophthalmic Artery
  • Retinal Neoplasms / pathology
  • Retinal Neoplasms / therapy*
  • Retinoblastoma / pathology
  • Retinoblastoma / therapy*


  • Antineoplastic Agents