The Combinational Polymorphisms of ORAI1 Gene Are Associated with Preventive Models of Breast Cancer in the Taiwanese

Fu Ou-Yang; Yu-Da Lin; Li-Yeh Chuang; Hsueh-Wei Chang; Cheng-Hong Yang; Ming-Feng Hou

doi:10.1155/2015/281263

The Combinational Polymorphisms of ORAI1 Gene Are Associated with Preventive Models of Breast Cancer in the Taiwanese

Biomed Res Int. 2015:2015:281263. doi: 10.1155/2015/281263. Epub 2015 Aug 25.

Authors

Fu Ou-Yang¹, Yu-Da Lin², Li-Yeh Chuang³, Hsueh-Wei Chang⁴, Cheng-Hong Yang², Ming-Feng Hou⁵

Affiliations

¹ Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan ; Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan ; Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan ; Department of Surgery, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan.
² Department of Electronic Engineering, National Kaohsiung University of Applied Sciences, Kaohsiung 80778, Taiwan.
³ Department of Chemical Engineering & Institute of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung 84001, Taiwan.
⁴ Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan ; Institute of Medical Science and Technology, National Sun Yat-sen University, Kaohsiung 80424, Taiwan ; Research Center of Environmental Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan ; Department of Biomedical Science and Environmental Biology, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
⁵ Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80708, Taiwan ; Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan ; Department of Surgery, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan ; National Sun Yat-Sen University-Kaohsiung Medical University Joint Research Center, Kaohsiung 80424, Taiwan ; Department of Biological Science and Technology, National Chiao Tung University, Hsinchu 30010, Taiwan.

Abstract

The ORAI calcium release-activated calcium modulator 1 (ORAI1) has been proven to be an important gene for breast cancer progression and metastasis. However, the protective association model between the single nucleotide polymorphisms (SNPs) of ORAI1 gene was not investigated. Based on a published data set of 345 female breast cancer patients and 290 female controls, we used a particle swarm optimization (PSO) algorithm to identify the possible protective models of breast cancer association in terms of the SNPs of ORAI1 gene. Results showed that the PSO-generated models of 2-SNP (rs12320939-TT/rs12313273-CC), 3-SNP (rs12320939-TT/rs12313273-CC/rs712853-(TT/TC)), 4-SNP (rs12320939-TT/rs12313273-CC/rs7135617-(GG/GT)/rs712853-(TT/TC)), and 5-SNP (rs12320939-TT/rs12313273-CC/rs7135617-(GG/GT)/rs6486795-CC/rs712853-(TT/TC)) displayed low values of odds ratios (0.409-0.425) for breast cancer association. Taken together, these results suggested that our proposed PSO strategy is powerful to identify the combinational SNPs of rs12320939, rs12313273, rs7135617, rs6486795, and rs712853 of ORAI1 gene with a strongly protective association in breast cancer.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Algorithms
Breast Neoplasms / epidemiology
Breast Neoplasms / genetics*
Calcium Channels / genetics*
Case-Control Studies
Computational Biology / methods
Databases, Genetic
Female
Genetic Predisposition to Disease / genetics*
Humans
ORAI1 Protein
Polymorphism, Single Nucleotide / genetics*
Risk
Taiwan / epidemiology

Substances

Calcium Channels
ORAI1 Protein
ORAI1 protein, human