1 1 Department of Anesthesia, St Michael's Hospital, and The Critical Illness and Injury Research Centre, Keenan Research Centre for Biomedical Science of St Michael's Hospital, Toronto, Ontario, Canada ; 2 Department of Anesthesia, 3 Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Ontario, Canada ; 4 Department of Medicine, St Michael's Hospital, and The Critical Illness and Injury Research Centre, Keenan Research Centre for Biomedical Science of St Michael's Hospital, Toronto, Ontario, Canada.