Knockdown of either filaggrin or loricrin increases the productions of interleukin (IL)-1α, IL-8, IL-18 and granulocyte macrophage colony-stimulating factor in stratified human keratinocytes

J Dermatol Sci. 2015 Nov;80(2):158-60. doi: 10.1016/j.jdermsci.2015.09.002. Epub 2015 Sep 7.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cells, Cultured
  • Down-Regulation
  • Gene Knockdown Techniques*
  • Granulocyte Colony-Stimulating Factor / metabolism*
  • Humans
  • Interleukin-18 / metabolism*
  • Interleukin-1alpha / metabolism*
  • Interleukin-8 / metabolism*
  • Intermediate Filament Proteins / genetics
  • Intermediate Filament Proteins / metabolism*
  • Keratinocytes / immunology
  • Keratinocytes / metabolism*
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism*
  • RNA Interference
  • Transfection
  • Up-Regulation

Substances

  • CXCL8 protein, human
  • IL1A protein, human
  • Interleukin-18
  • Interleukin-1alpha
  • Interleukin-8
  • Intermediate Filament Proteins
  • Membrane Proteins
  • filaggrin
  • loricrin
  • Granulocyte Colony-Stimulating Factor