Evaluation of ADAMTS12, ADAMTS16, ADAMTS18 and IL-33 serum levels in pre-eclampsia

J Matern Fetal Neonatal Med. 2016;29(15):2451-6. doi: 10.3109/14767058.2015.1087497. Epub 2015 Sep 18.


Objective: Pre-eclampsia is the result of impaired trophoblast invasion and spiral artery remodeling managed by inflammatory response in its etiology and physiopathology. The aim of this study was to compare serum molecules including IL-33, ADAMTS12, ADAMTS16 and ADAMTS18 levels between pre-eclampsia and control groups and to investigate the role of these molecules in pre-eclampsia.

Methods: Forty-one women diagnosed as pre-eclampsia between 30 and 40 weeks of gestation and 41 non-complicated pregnant women were enrolled in this cross-sectional, case-control prospective study. ELISA method was used to determine IL-33, ADAMTS12, ADAMTS16 and ADAMTS18 levels within serums in two groups.

Results: Serum ADAMTS12 and IL-33 levels were significantly lower in pre-eclampsia group (p < 0.001 and p: 0.028, respectively), however, in sub-group analysis, no significant difference was observed (p > 0.05). The cut-off value of ADAMTS12 levels to discriminate pre-eclampsia with %73.17 sensitivity and %92.68 specificity was 8.27 ng/ml while the cut-off value for IL-33 was 0.23 pg/ml with 82.93% sensitivity and 53.66% specificity.

Conclusion: Pre-eclampsia is associated with lower serum IL-33 and ADAMTS12 levels.

Keywords: ADAMTS12; ADAMTS16; ADAMTS18; IL-33; pre-eclampsia.

MeSH terms

  • ADAMTS Proteins / blood*
  • Adult
  • Case-Control Studies
  • Cross-Sectional Studies
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Interleukin-33 / blood*
  • Pre-Eclampsia / blood*
  • Pregnancy
  • Prospective Studies
  • Sensitivity and Specificity


  • IL33 protein, human
  • Interleukin-33
  • ADAMTS Proteins
  • ADAMTS12 protein, human
  • ADAMTS16 protein, human
  • ADAMTS18 protein, human