Check, Check …Triple Check: Multi-Step DNA Lesion Identification by Nucleotide Excision Repair

Mol Cell. 2015 Sep 17;59(6):885-6. doi: 10.1016/j.molcel.2015.09.007.


In this issue, Li et al. (2015) uncover roles for the XPB and XPD helicases and for XPA during damage verification in nucleotide excision repair, supporting a novel tripartite damage checking mechanism that combines extreme versatility with narrow specificity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • DNA Adducts / genetics*
  • DNA-Binding Proteins / physiology*
  • Humans
  • Transcription Factor TFIIH / physiology*
  • Xeroderma Pigmentosum Group A Protein / physiology*


  • DNA Adducts
  • DNA-Binding Proteins
  • Xeroderma Pigmentosum Group A Protein
  • Transcription Factor TFIIH