Check, Check …Triple Check: Multi-Step DNA Lesion Identification by Nucleotide Excision Repair

Jurgen A Marteijn; Jan H J Hoeijmakers; Wim Vermeulen

doi:10.1016/j.molcel.2015.09.007

Check, Check …Triple Check: Multi-Step DNA Lesion Identification by Nucleotide Excision Repair

Mol Cell. 2015 Sep 17;59(6):885-6. doi: 10.1016/j.molcel.2015.09.007.

Authors

Jurgen A Marteijn¹, Jan H J Hoeijmakers², Wim Vermeulen¹

Affiliations

¹ Department of Genetics, Cancer Genomics Netherlands, Erasmus University Medical Center, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands.
² Department of Genetics, Cancer Genomics Netherlands, Erasmus University Medical Center, Wytemaweg 80, 3015 CN Rotterdam, The Netherlands. Electronic address: j.hoeijmakers@erasmusmc.nl.

PMID: 26384662
DOI: 10.1016/j.molcel.2015.09.007

Abstract

In this issue, Li et al. (2015) uncover roles for the XPB and XPD helicases and for XPA during damage verification in nucleotide excision repair, supporting a novel tripartite damage checking mechanism that combines extreme versatility with narrow specificity.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
DNA Adducts / genetics*
DNA-Binding Proteins / physiology*
Humans
Transcription Factor TFIIH / physiology*
Xeroderma Pigmentosum Group A Protein / physiology*

Substances

DNA Adducts
DNA-Binding Proteins
Xeroderma Pigmentosum Group A Protein
Transcription Factor TFIIH