Deep Brain Recordings Using an Implanted Pulse Generator in Parkinson's Disease

Neuromodulation. 2016 Jan;19(1):20-24. doi: 10.1111/ner.12348. Epub 2015 Sep 21.


Objectives: Recent studies suggest that oscillatory beta activity could be used as a state biomarker in patients with Parkinson's disease for subthalamic closed-loop stimulation with the intention of improving clinical benefit. Here we investigate the feasibility of subthalamic recordings via a novel chronically implanted pulse generator.

Methods: Subthalamic local field potential recordings were obtained from eight patients before and during deep brain stimulation (DBS). All data were analyzed in the frequency domain using Fourier transform-based methods and compared between ON and OFF stimulation conditions.

Results: Distinct peaks of oscillatory beta band activity were found in 12 of 15 electrodes. DBS induced a significant frequency specific suppression of oscillatory beta activity (p = 0.002).

Conclusion: The results of the study suggest that oscillatory beta band synchronization and its modulation by DBS is recordable with a system suitable for chronic implantation and may serve as a biomarker for subthalamic closed-loop stimulation in patients with Parkinson's disease.

Keywords: Basal ganglia; beta oscillations; deep brain stimulation; local field potentials; subthalamic nucleus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Biophysics
  • Deep Brain Stimulation / methods*
  • Electrodes, Implanted
  • Evoked Potentials / physiology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease / therapy*
  • Spectrum Analysis
  • Subthalamic Nucleus / cytology*
  • Subthalamic Nucleus / physiology*