Lipid and small-molecule display by CD1 and MR1

Nat Rev Immunol. 2015 Oct;15(10):643-54. doi: 10.1038/nri3889. Epub 2015 Sep 21.

Abstract

The antigen-presenting molecules CD1 and MHC class I-related protein (MR1) display lipids and small molecules to T cells. The antigen display platforms in the four CD1 proteins are laterally asymmetrical, so that the T cell receptor (TCR)-binding surfaces are comprised of roofs and portals, rather than the long grooves seen in the MHC antigen-presenting molecules. TCRs can bind CD1 proteins with left-sided or right-sided footprints, creating unexpected modes of antigen recognition. The use of tetramers of human CD1a, CD1b, CD1c or MR1 proteins now allows detailed analysis of the human T cell repertoire, which has revealed new invariant TCRs that bind CD1b molecules and are different from those that define natural killer T cells and mucosal-associated invariant T cells.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Antigen Presentation / immunology
  • Antigens, CD1 / chemistry
  • Antigens, CD1 / immunology*
  • Antigens, CD1 / metabolism
  • Histocompatibility Antigens Class I / chemistry
  • Histocompatibility Antigens Class I / immunology*
  • Histocompatibility Antigens Class I / metabolism
  • Humans
  • Lipids / chemistry
  • Lipids / immunology*
  • Minor Histocompatibility Antigens
  • Models, Molecular
  • Protein Binding / immunology
  • Protein Structure, Tertiary
  • Receptors, Antigen, T-Cell / chemistry
  • Receptors, Antigen, T-Cell / immunology
  • Receptors, Antigen, T-Cell / metabolism
  • T-Lymphocytes / immunology
  • T-Lymphocytes / metabolism

Substances

  • Antigens, CD1
  • Histocompatibility Antigens Class I
  • Lipids
  • MR1 protein, human
  • Minor Histocompatibility Antigens
  • Receptors, Antigen, T-Cell