Selective Binding of DNA Origami on Biomimetic Lipid Patches

Small. 2015 Nov 18;11(43):5752-8. doi: 10.1002/smll.201501333. Epub 2015 Sep 21.

Abstract

Arrays of biomimetic lipid patches for studying the binding of DNA origami structures can be tailored in size, shape, and composition with the aid of lipid-dip pen nanolithography. This approach allows for analysis of the effects of lipid composition with high throughput which could be applied for the targeted presentation of functional DNA origami structures on surfaces.

Keywords: DNA origami; biomimetic membranes; dip-pen nanolithography; phospholipids; supported lipid bilayer membranes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adhesiveness
  • Binding Sites
  • Biomimetic Materials / chemistry*
  • DNA / chemistry*
  • DNA / ultrastructure*
  • Lipid Bilayers / chemistry*
  • Materials Testing / methods
  • Microarray Analysis / methods*
  • Molecular Imprinting / methods*
  • Nucleic Acid Conformation
  • Phosphatidylcholines / chemistry
  • Structure-Activity Relationship

Substances

  • Lipid Bilayers
  • Phosphatidylcholines
  • DNA
  • 1,2-oleoylphosphatidylcholine