Protein lysine acetylation in bacteria: Current state of the art

Proteomics. 2016 Jan;16(2):301-9. doi: 10.1002/pmic.201500258. Epub 2015 Dec 14.


Post-translational modifications of proteins are key events in cellular metabolism and physiology regulation. Lysine acetylation is one of the best studied protein modifications in eukaryotes, but, until recently, ignored in bacteria. However, proteomic advances have highlighted the diversity of bacterial lysine-acetylated proteins. The current data support the implication of lysine acetylation in various metabolic pathways, adaptation and virulence. In this review, we present a broad overview of the current knowledge of lysine acetylation in bacteria. We emphasize particularly the significant contribution of proteomics in this field.

Keywords: Bacteria; Lysine acetylation; Microbiology.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Acetylation
  • Bacteria / metabolism*
  • Bacterial Proteins / metabolism*
  • Humans
  • Lysine / metabolism
  • Metabolic Networks and Pathways
  • Protein Processing, Post-Translational*
  • Proteomics


  • Bacterial Proteins
  • Lysine