High Salt Intake Is Independently Associated With Hypertensive Target Organ Damage

J Clin Hypertens (Greenwich). 2016 Apr;18(4):315-21. doi: 10.1111/jch.12668. Epub 2015 Sep 22.


The authors tested the hypothesis that high salt intake is associated with hypertensive target organ damage (TOD) independent of blood pressure (BP), and oxidative stress is a modifying factor of this association. A total of 369 community-dwelling Japanese adults (mean age, 67.5 years; 56.6% women) were examined in this observational study. At the patients' annual health check-ups, urinary salt excretion (U-SALT), 8-hydroxy-2'-deoxyguanosine (8-OHdG), and albumin-creatinine ratio (UACR) were measured from first morning urine. U-SALT (β=0.14, P=.016) and 8-OHdG (β=0.13, P=.018) were both independently associated with logUACR. U-SALT was associated with TOD independent of BP level, and oxidative stress may be a modifying factor in the association between high salt intake and TOD. The elevation of 8-OHdG may be involved in the pathophysiology of TOD induced by salt intake.

Publication types

  • Observational Study

MeSH terms

  • Aged
  • Biomarkers / urine
  • Blood Pressure / drug effects*
  • Blood Pressure Determination
  • Cross-Sectional Studies
  • Female
  • Follow-Up Studies
  • Humans
  • Hypertension / epidemiology
  • Hypertension / physiopathology*
  • Hypertension / urine
  • Japan / epidemiology
  • Male
  • Morbidity / trends
  • Prognosis
  • Retrospective Studies
  • Risk Factors
  • Sodium Chloride / urine*
  • Sodium Chloride, Dietary / adverse effects*
  • Sodium Chloride, Dietary / pharmacokinetics
  • Survival Rate / trends


  • Biomarkers
  • Sodium Chloride, Dietary
  • Sodium Chloride