Wavelet analysis of skin perfusion to assess the effects of FREMS therapy before and after occlusive reactive hyperemia

Med Eng Phys. 2015 Nov;37(11):1111-5. doi: 10.1016/j.medengphy.2015.08.016. Epub 2015 Sep 29.


Laser Doppler Fluxmetry is used to evaluate the hemodynamics of skin microcirculation. Laser Doppler signals contain oscillations due to fluctuations of microvascular perfusion. By performing spectral analysis, six frequency intervals from 0.005 to 2 Hz have been identified and assigned to distinct cardiovascular structures: heart, respiration, vascular myocites, sympathetic terminations and endothelial cells (dependent and independent on nitric oxide). Transcutaneous electrical pulses are currently applied to treat several diseases, i.e. neuropathies and chronic painful leg ulcers. Recently, FREMS (Frequency Rhythmic Electrical Modulation System) has been applied to vasculopathic patients, too. In this study Laser Doppler signals of skin microcirculation were measured in five patients with intermittent claudication, before and after the FREMS therapy. Changes in vascular activities were assessed by wavelet transform analysis. Preliminary results demonstrate that FREMS induces alterations in vascular activities.

Keywords: Microcirculation; Transcutaneous electric stimulation; Wavelet transform.

Publication types

  • Observational Study

MeSH terms

  • Aged
  • Artifacts
  • Electric Stimulation Therapy* / methods
  • Hemodynamics / physiology
  • Humans
  • Hyperemia / physiopathology
  • Hyperemia / therapy*
  • Laser-Doppler Flowmetry / methods*
  • Leg / blood supply
  • Leg / physiopathology
  • Microcirculation / physiology*
  • Rest
  • Skin / blood supply*
  • Treatment Outcome
  • Wavelet Analysis*