Novel perspectives of long non-coding RNAs in esophageal carcinoma

Chen-Yu Lin; Han-Mei Xu

doi:10.1093/carcin/bgv136

Novel perspectives of long non-coding RNAs in esophageal carcinoma

Carcinogenesis. 2015 Nov;36(11):1255-62. doi: 10.1093/carcin/bgv136. Epub 2015 Sep 21.

Authors

Chen-Yu Lin¹, Han-Mei Xu²

Affiliations

¹ Department of The Engineering Research Center of Peptide Drug Discovery and Development and Department of State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, P. R. China.
² Department of The Engineering Research Center of Peptide Drug Discovery and Development and Department of State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, P. R. China 13913925346@126.com.

PMID: 26392258
DOI: 10.1093/carcin/bgv136

Abstract

Esophageal carcinoma (EC) is one of the most aggressive cancer types worldwide. However, the underlying genomic events of EC are not fully understood. It is becoming evident that long non-coding RNAs (lncRNAs) play vital roles in tumorgenesis, metastasis, prognosis and diagnosis. Accumulating EC-related lncRNAs have been verified to involve in various biological processes through diverse functions including signal, decoy, scaffold and guide. However, the molecular mechanism of lncRNAs in EC has not been fully explored. In this review, we outline the functions and underlying mechanism of EC-related lncRNAs to pave the way for identification of novel potential biomarkers for EC.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Biomarkers, Tumor / genetics
Biomarkers, Tumor / metabolism*
Carcinogenesis / genetics
Carcinogenesis / metabolism
Esophageal Neoplasms / diagnosis
Esophageal Neoplasms / genetics*
Esophageal Neoplasms / metabolism
Gene Expression
Humans
Prognosis
RNA, Long Noncoding / genetics
RNA, Long Noncoding / metabolism*

Substances

Biomarkers, Tumor
RNA, Long Noncoding