The role of the transcription factor Ets1 in carcinoma

Semin Cancer Biol. 2015 Dec;35:20-38. doi: 10.1016/j.semcancer.2015.09.010. Epub 2015 Sep 25.

Abstract

Ets1 belongs to the large family of the ETS domain family of transcription factors and is involved in cancer progression. In most carcinomas, Ets1 expression is linked to poor survival. In breast cancer, Ets1 is primarily expressed in the triple-negative subtype, which is associated with unfavorable prognosis. Ets1 contributes to the acquisition of cancer cell invasiveness, to EMT (epithelial-to-mesenchymal transition), to the development of drug resistance and neo-angiogenesis. The aim of this review is to summarize the current knowledge on the functions of Ets1 in carcinoma progression and on the mechanisms that regulate Ets1 activity in cancer.

Keywords: Drug resistance; EMT; Ets1; Triple-negative breast cancer.

Publication types

  • Review

MeSH terms

  • Animals
  • Carcinoma / drug therapy
  • Carcinoma / genetics*
  • Carcinoma / metabolism*
  • Carcinoma / mortality
  • Carcinoma / pathology
  • Disease Progression
  • Drug Resistance, Neoplasm / genetics
  • Epithelial-Mesenchymal Transition / genetics
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Neovascularization, Pathologic / genetics
  • Neovascularization, Pathologic / metabolism
  • Phosphorylation
  • Prognosis
  • Protein Binding
  • Protein Interaction Domains and Motifs
  • Protein Processing, Post-Translational
  • Proto-Oncogene Protein c-ets-1 / chemistry
  • Proto-Oncogene Protein c-ets-1 / genetics
  • Proto-Oncogene Protein c-ets-1 / metabolism*
  • RNA Interference
  • Signal Transduction

Substances

  • Proto-Oncogene Protein c-ets-1