American ginseng tea protects cellular DNA within 2 h from consumption: results of a pilot study in healthy human volunteers

Int J Food Sci Nutr. 2015;66(7):815-8. doi: 10.3109/09637486.2015.1088937. Epub 2015 Sep 22.


The acute genoprotective effect of Panax quinquefolius (American ginseng) has been investigated. The experiment was carried out to explore the DNA protective effect after a single dose of American ginseng tea bag infusion. Fourteen subjects (6 males and 8 females) were recruited in this study. Seven of them (3 males and 4 females) were asked to drink a cup of freshly prepared American ginseng infusions. Water was taken by the remaining subjects as the control group. Blood samples of both groups were taken before and 2 h post-ingestion. The blood samples were challenged with ultraviolet B irradiation followed by using comet assay. Completed slides were stained with Giemsa stain and DNA damage was assessed. Results showed a significant decrease in comet score after American ginseng supplementation and no change in the control group. The current study demonstrated a cup of American ginseng infusion could protect cellular DNA from oxidative stress at least within 2 h.

Keywords: American ginseng; DNA protection; UV; antioxidant; comet assay.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antioxidants / pharmacology*
  • Comet Assay
  • DNA / drug effects*
  • DNA / metabolism
  • DNA / radiation effects
  • DNA Damage*
  • Female
  • Healthy Volunteers
  • Humans
  • Male
  • Middle Aged
  • Oxidative Stress / drug effects*
  • Panax / chemistry*
  • Phytotherapy
  • Pilot Projects
  • Plant Extracts / pharmacology*
  • Ultraviolet Rays
  • Young Adult


  • Antioxidants
  • Plant Extracts
  • DNA