Neurodegeneration: The Size Takes It All

Sandra Franco-Iborra; Celine Perier

doi:10.1016/j.cub.2015.07.062

Neurodegeneration: The Size Takes It All

Curr Biol. 2015 Sep 21;25(18):R797-800. doi: 10.1016/j.cub.2015.07.062.

Authors

Sandra Franco-Iborra¹, Celine Perier²

Affiliations

¹ Vall d'Hebron Research Institute-CIBERNED, Neurodegenerative Diseases Research Group, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain.
² Vall d'Hebron Research Institute-CIBERNED, Neurodegenerative Diseases Research Group, Passeig Vall d'Hebron 119-129, 08035 Barcelona, Spain. Electronic address: celine.perier@vhir.org.

PMID: 26394101
DOI: 10.1016/j.cub.2015.07.062

Abstract

There is increasing computational evidence that the exceptionally high vulnerability of dopaminergic neurons in Parkinson's disease may be due to their unique axonal architecture and resulting metabolic needs. A new experimental study has actually demonstrated this.

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MeSH terms

Animals
Axons / physiology*
Dopaminergic Neurons / physiology*
Energy Metabolism*
Mitochondria / metabolism*
Neuronal Plasticity*