Scoliosis-related factors in patients with rheumatoid arthritis: A cross-sectional study

Mod Rheumatol. 2016;26(3):352-7. doi: 10.3109/14397595.2015.1097016. Epub 2015 Nov 3.

Abstract

Objectives: This study aimed to identify the prevalence of scoliosis and scoliosis-related factors of rheumatoid arthritis (RA).

Methods: In this study, 411 patients who underwent coronal total spine and lower limb radiography were enrolled. Patients with a Cobb angle ≥10° were diagnosed with scoliosis. Statistical analysis was performed to compare between patients with and those without scoliosis, and between patients without scoliosis and those with a Cobb angle >20°.

Results: The prevalence of scoliosis in patients with RA was 30.7%. The mean Cobb angles were 8.5° ± 7.2° in all the patients, 16.1° ± 8.6° in patients with scoliosis, and 5.1° ± 2.3° in patients without scoliosis. According to a multivariate analysis, the scoliosis-related factors of RA were age and vertebral fracture. Significant differences in age, corticosteroid use, and malalignment of lower limbs were observed between patients with a Cobb angle >20° and those without scoliosis.

Conclusions: With RA treatment, the need for corticosteroid use is reduced and vertebral fracture is prevented. Moreover, the joints and spinal and lower limb alignments should be examined.

Keywords: Age; Alignment of lower limbs; Corticosteroid; Rheumatoid arthritis; Scoliosis.

MeSH terms

  • Aged
  • Arthritis, Rheumatoid / complications
  • Arthritis, Rheumatoid / epidemiology*
  • Cross-Sectional Studies
  • Female
  • Humans
  • Incidence
  • Japan / epidemiology
  • Male
  • Middle Aged
  • Prevalence
  • Risk Assessment / methods*
  • Risk Factors
  • Scoliosis / epidemiology*
  • Scoliosis / etiology