Dumping Syndrome: A Review of the Current Concepts of Pathophysiology, Diagnosis, and Treatment

Dig Dis Sci. 2016 Jan;61(1):11-8. doi: 10.1007/s10620-015-3839-x. Epub 2015 Sep 22.


Gastric surgery has long been known to be a cause of dumping syndrome (DS). However, the increasing incidence of gastric bypass surgery, as well as reports of DS unrelated to previous gastric surgeries, has increased the importance of understanding DS in recent years. DS is due to the gastrointestinal response to voluminous and hyperosmolar chyme that is rapidly expelled from the stomach into the small intestine. This response involves neural and hormonal mechanisms. This review encompasses the symptoms, diagnosis, and treatment approaches of DS and also focuses on the current research status of the pathophysiology of DS.

Keywords: Bariatric surgery; Dumping syndrome; Gastric surgery; Idiopathic dumping syndrome.

Publication types

  • Review

MeSH terms

  • Diagnosis, Differential
  • Dumping Syndrome* / diagnosis
  • Dumping Syndrome* / epidemiology
  • Dumping Syndrome* / physiopathology
  • Dumping Syndrome* / therapy
  • Gastric Bypass / adverse effects*
  • Humans
  • Predictive Value of Tests
  • Prognosis
  • Risk Factors