Combination of Diffusion Tensor Imaging and Conventional MRI Correlates With Isocitrate Dehydrogenase 1/2 Mutations but Not 1p/19q Genotyping in Oligodendroglial Tumours

Eur Radiol. 2016 Jun;26(6):1705-15. doi: 10.1007/s00330-015-4025-4. Epub 2015 Sep 22.

Abstract

Objectives: To explore the correlations of conventional MRI (cMRI) and diffusion tensor imaging (DTI) values with the 1p/19 codeletion and IDH mutations in oligodendroglial tumours (OTs).

Methods: Eighty-four patients with OTs who underwent cMRI and DTI were retrospectively reviewed. The maximal fractional anisotropy and minimal apparent diffusion coefficient (ADC) were measured and compared using the Mann-Whitney U test. Receiver operating characteristic curves, logistic regression analysis and four-table statistics analysis were performed to predict genotypings.

Results: OTs with 1p/19q codeletion or IDH mutations were prone to locate in frontal (P = 0.106 and 0.005, respectively) and insular lobes and were associated with absent or blurry contrast enhancement (P = 0.040 and 0.013, respectively). DTI values showed significant differences between OTs with and without IDH mutations (P < 0.05) but not in OTs with and without 1p/19q loss. The Ki-67 index significantly correlated with IDH mutations (P = 0.002) but not with 1p/19q codeletion. A combination of DTI and cMRI for the identification of IDH mutations resulted in sensitivity, specificity, positive and negative predictive values of 92.2 %, 75.8 %, 93.8 % and 71.1 %, respectively.

Conclusions: Combination of DTI and cMRI correlates with isocitrate dehydrogenase 1/2 mutations but not 1p/19q genotyping in OTs.

Key points: • OTs with 1p/19q codeletion were associated with absent or blurry contrast enhancement • OTs with IDH mutations were also associated with absent or blurry contrast enhancement • OTs with IDH mutations were prone to locate in frontal and insular lobes • DTI values can provide a non-invasive method for assessing the IDH status of OTs • A combination of DTI and cMRI correlates with isocitrate dehydrogenase 1/2 mutations.

Keywords: 1p/19q codeletion; Conventional MRI; Diffusion tensor imaging; Isocitrate dehydrogenase gene; Oligodendroglial tumours.

MeSH terms

  • Adult
  • Brain Neoplasms / genetics*
  • Brain Neoplasms / pathology
  • Cerebral Cortex / pathology
  • Diffusion Tensor Imaging / methods
  • Female
  • Genotype
  • Humans
  • Isocitrate Dehydrogenase / genetics*
  • Magnetic Resonance Imaging / methods
  • Male
  • Middle Aged
  • Multimodal Imaging
  • Mutation / genetics*
  • Oligodendroglioma / genetics*
  • Oligodendroglioma / pathology
  • Retrospective Studies
  • Sensitivity and Specificity

Substances

  • Isocitrate Dehydrogenase