Excessive dietary phosphorus intake impairs endothelial function in young healthy men: a time- and dose-dependent study

J Med Invest. 2015;62(3-4):167-72. doi: 10.2152/jmi.62.167.


Excessive dietary phosphorus (P) has been speculated to be a risk factor for cardiovascular disease (CVD). Here, we performed a double-blinded crossover study to investigate the time- and dose-dependent effects of dietary P intake on endothelial function in healthy subjects. Sixteen healthy male volunteers were given meals containing 400, 800, and 1,200 mg P (P400, P800, and P1200 meals, respectively) with at least 7 days between doses. There were no differences in nutritional composition among the experimental diets except for P content. Blood biochemistry data and flow-mediated dilation (%FMD) of the brachial artery were measured while fasted, at 0 h, 1 h, 2 h, and 4 h after meal ingestion, and the next morning while fasted. The P800 and P1200 meals significantly increased serum P levels at 1-4 h after ingestion. A significant decrease in %FMD was observed between 1-4 h,while the P400 meal did not affect %FMD. We observed no differences among meals in serum P levels or %FMD the next morning. A significant negative correlation was observed between %FMD and serum P. These results indicate that excessive dietary P intake can acutely impair endothelial function in healthy people.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Brachial Artery / physiology
  • Cross-Over Studies
  • Double-Blind Method
  • Endothelium, Vascular / physiology*
  • Humans
  • Male
  • Phosphorus / blood
  • Phosphorus, Dietary / administration & dosage*
  • Time Factors
  • Vasodilation


  • Phosphorus, Dietary
  • Phosphorus