Hallmarks of Pluripotency

Nature. 2015 Sep 24;525(7570):469-78. doi: 10.1038/nature15515.

Abstract

Stem cells self-renew and generate specialized progeny through differentiation, but vary in the range of cells and tissues they generate, a property called developmental potency. Pluripotent stem cells produce all cells of an organism, while multipotent or unipotent stem cells regenerate only specific lineages or tissues. Defining stem-cell potency relies upon functional assays and diagnostic transcriptional, epigenetic and metabolic states. Here we describe functional and molecular hallmarks of pluripotent stem cells, propose a checklist for their evaluation, and illustrate how forensic genomics can validate their provenance.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Embryonic Stem Cells / cytology
  • Embryonic Stem Cells / metabolism
  • Genomics
  • Humans
  • Pluripotent Stem Cells / cytology*
  • Pluripotent Stem Cells / metabolism*