Multiple chronic conditions and healthcare costs among adults

Expert Rev Pharmacoecon Outcomes Res. 2015;15(5):823-32. doi: 10.1586/14737167.2015.1091730.


The prevalence of multiple chronic conditions (MCC) is increasing among individuals of all ages. MCC are associated with poor health outcomes. The presence of MCC has profound healthcare utilization and cost implications for public and private insurance payers, individuals, and families. Investigators have used a variety of definitions for MCC to evaluate costs associated with MCC. The objective of this article is to examine the current literature in estimating excess costs associated with MCC among adults. The discussion highlights some of the theoretical and technical merits of various MCC definitions and models used to estimate the excess costs associated with MCC.

Keywords: comorbidity; cost burden; expenditures; multimorbidity; multiple chronic conditions; out-of-pocket costs.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adult
  • Chronic Disease / economics*
  • Chronic Disease / epidemiology
  • Comorbidity
  • Health Care Costs*
  • Health Services / economics
  • Health Services / statistics & numerical data
  • Humans
  • Insurance, Health / economics
  • Models, Economic*