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Case Reports
. 2015 Jul 1;13(3):e28383.
doi: 10.5812/ijem.28383v2. eCollection 2015 Jul.

Pituitary Stone or Calcified Pituitary Tumor? Three Cases and Literature Review

Free PMC article
Case Reports

Pituitary Stone or Calcified Pituitary Tumor? Three Cases and Literature Review

Farida Chentli et al. Int J Endocrinol Metab. .
Free PMC article


Introduction: Pituitary stone or pituitary calculus is a scientific enigma characterized by a large calcification in the pituitary sella. It can be discovered incidentally or in a patient with endocrine and/or neurological problems. Its mechanism is not understood. In this article, we described three patients harboring a large pituitary calcification.

Case presentation: The first case was observed in a 27-year-old woman who consulted for secondary amenorrhea. The second case concerned a woman who consulted for infertility, and the third one was observed in an 11-year and nine-month-old girl who was sent to our department for short stature. Clinical examination was normal in both adults. The pediatric case had dwarfism with lack of pubertal development. Hormonal assessment showed hyperprolactinemia in both women and thyrotroph and somatotroph deficits in the child. Radiologic exploration discovered pituitary calcifications measuring 10, 11, and 45 mm without any cystic or solid mass.

Conclusions: Radiological findings pleaded for a pituitary stone, but calcified adenomas in women, and calcified craniopharyngioma in the pediatric case could not be excluded, as our three patients were not operated on.

Keywords: Heterotopic Ossification; Hyperprolactinemia; Hypopituitarism; Pituitary Gland.


Figure 1.
Figure 1.. Computed Tomographic Scan and Magnetic Resonance Imaging of Pituitary Gland
Case 1; A, Cerebral Computed tomographic (CT) scan showing the pituitary calcification (arrow) with intact sellar floor. B, Magnetic resonance imaging (MRI) showing a hyposignal mass in the sella turcica; Case 2; Left pituitary calcified mass measuring 11 mm suggestive of a pituitary stone on CT scans (C, D, E) and MRI (F, G); Case 3; CT scan showing a completely calcified pituitary process (H, I).

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