Nickel(II) and cobalt(II) complexes of lidocaine: Synthesis, structure and comparative in vitro evaluations of biological perspectives

Leila Tabrizi; Patrick McArdle; Andrea Erxleben; Hossein Chiniforoshan

doi:10.1016/j.ejmech.2015.09.018

Nickel(II) and cobalt(II) complexes of lidocaine: Synthesis, structure and comparative in vitro evaluations of biological perspectives

Eur J Med Chem. 2015 Oct 20:103:516-29. doi: 10.1016/j.ejmech.2015.09.018. Epub 2015 Sep 15.

Authors

Leila Tabrizi¹, Patrick McArdle², Andrea Erxleben³, Hossein Chiniforoshan⁴

Affiliations

¹ Department of Chemistry, Isfahan University of Technology, Isfahan 84156-83111, Iran; School of Chemistry, National University of Ireland Galway, University Road, Galway, Ireland.
² School of Chemistry, National University of Ireland Galway, University Road, Galway, Ireland. Electronic address: p.mcardle@nuigalway.ie.
³ School of Chemistry, National University of Ireland Galway, University Road, Galway, Ireland. Electronic address: andrea.erxleben@nuigalway.ie.
⁴ Department of Chemistry, Isfahan University of Technology, Isfahan 84156-83111, Iran.

PMID: 26402729
DOI: 10.1016/j.ejmech.2015.09.018

Abstract

Metal complexes of the type [Ni(LC)2(X)2], 1 and 2, [Co(LC)2(X)2], 3 and 4 (LC: lidocaine, X = dca (dicyanamide), 1 and 3, X = NCS(-), 2 and 4) have been synthesized and characterized. The geometries of 1-4 were confirmed by single crystal X-ray crystallography. The complexes are water soluble and stable in aqueous solution. The interaction of 1-4 with calf thymus DNA (CT DNA) and bovine serum albumin (BSA) was investigated using UV-visible and fluorescence spectrophotometric methods. A gel electrophoresis assay demonstrated that the complexes cleave pUC19 plasmid DNA. The in vitro free radical scavenging, antimicrobial activity and cytotoxic potential of all the complexes were examined.

Keywords: BSA binding; Cobalt(II) complexes; Cytotoxicity; DNA binding; DNA cleavage; Lidocaine; Nickel(II) complexes.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemical synthesis
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Antineoplastic Agents / chemical synthesis
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology*
Bacteria / drug effects
Cell Line, Tumor
Cell Proliferation / drug effects
Cobalt / chemistry*
Crystallography, X-Ray
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Free Radical Scavengers / chemical synthesis
Free Radical Scavengers / chemistry
Free Radical Scavengers / pharmacology*
Humans
Lidocaine / chemistry*
Lidocaine / pharmacology*
Microbial Sensitivity Tests
Models, Molecular
Molecular Structure
Nickel / chemistry*
Structure-Activity Relationship

Substances

Anti-Bacterial Agents
Antineoplastic Agents
Free Radical Scavengers
Cobalt
Nickel
Lidocaine