Intrinsic and extrinsic mechanical properties related to the differentiation of mesenchymal stem cells

Biochem Biophys Res Commun. 2016 May 6;473(3):752-7. doi: 10.1016/j.bbrc.2015.09.081. Epub 2015 Sep 25.


Diverse intrinsic and extrinsic mechanical factors have a strong influence on the regulation of stem cell fate. In this work, we examined recent literature on the effects of mechanical environments on stem cells, especially on differentiation of mesenchymal stem cells (MSCs). We provide a brief review of intrinsic mechanical properties of single MSC and examined the correlation between the intrinsic mechanical property of MSC and the differentiation ability. The effects of extrinsic mechanical factors relevant to the differentiation of MSCs were considered separately. The effect of nanostructure and elasticity of the matrix on the differentiation of MSCs were summarized. Finally, we consider how the extrinsic mechanical properties transfer to MSCs and then how the effects on the intrinsic mechanical properties affect stem cell differentiation.

Keywords: Differentiation; Mechanical property; Mechanotransduction; Mesenchymal stem cells.

Publication types

  • Review

MeSH terms

  • Adipocytes / cytology
  • Cell Differentiation*
  • Cell Lineage
  • Dimethylpolysiloxanes / chemistry
  • Elasticity
  • Humans
  • Mesenchymal Stem Cells / cytology*
  • Nanostructures / chemistry
  • Osteoblasts / cytology
  • Osteogenesis
  • Pressure
  • Stress, Mechanical


  • Dimethylpolysiloxanes
  • baysilon