Chlorella vulgaris Attenuates Dermatophagoides Farinae-Induced Atopic Dermatitis-Like Symptoms in NC/Nga Mice

Int J Mol Sci. 2015 Sep 2;16(9):21021-34. doi: 10.3390/ijms160921021.


Atopic dermatitis (AD) is a chronic and inflammatory skin disease that can place a significant burden on quality of life for patients. AD most frequently appears under the age of six and although its prevalence is increasing worldwide, therapeutic treatment options are limited. Chlorella vulgaris (CV) is a species of the freshwater green algae genus chlorella, and has been reported to modulate allergy-inducible factors when ingested. Here, we examined the effect of CV supplementation on AD-like symptoms in NC/Nga mice. CV was orally administrated for six weeks while AD-like symptoms were induced via topical application of Dermatophagoides farinae extract (DFE). CV treatment reduced dermatitis scores, epidermal thickness, and skin hydration. Histological analysis also revealed that CV treatment reduced DFE-induced eosinophil and mast cell infiltration into the skin, while analysis of serum chemokine levels indicated that CV treatment downregulated thymus- and activation-regulated chemokine (TARC) and macrophage-derived chemokine (MDC) levels. In addition, CV treatment downregulated mRNA expression levels of IL-4 and IFN-γ. Taken together, these results suggest that CV extract may have potential as a nutraceutical ingredient for the prevention of AD.

Keywords: atopic dermatitis; chlorella vulgaris; immune cell infiltration; inflammatory cytokines; inflammatory skin lesions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chemokines / blood
  • Chlorella vulgaris / chemistry*
  • Dermatitis, Atopic / drug therapy*
  • Dermatitis, Atopic / immunology
  • Dermatitis, Atopic / parasitology
  • Dermatophagoides farinae / pathogenicity*
  • Dietary Supplements / microbiology*
  • Disease Models, Animal
  • Drug Administration Schedule
  • Eosinophils / drug effects
  • Gene Expression Regulation / drug effects
  • Humans
  • Immunosuppressive Agents / administration & dosage*
  • Male
  • Mast Cells / drug effects
  • Mice


  • Chemokines
  • Immunosuppressive Agents