Mitochondria Cripple without Krüppel

Trends Endocrinol Metab. 2015 Nov;26(11):587-589. doi: 10.1016/j.tem.2015.08.004. Epub 2015 Sep 21.

Abstract

Proper mitochondrial biogenesis and removal is crucial in maintaining a healthy heart. Liao et al now show key roles for cardiac KLF4 in mitochondrial homeostasis via its interaction with the ERR/PGC-1 module, and mitochondrial clearance via regulation of mitophagy. Disruption of KLF4 leads to profoundly injured mitochondria and cardiac failure.

Publication types

  • Comment

MeSH terms

  • Animals
  • Humans
  • Kruppel-Like Transcription Factors / metabolism*
  • Mitochondria, Heart / metabolism*
  • Myocytes, Cardiac / metabolism*
  • Transcription, Genetic*

Substances

  • Kruppel-Like Transcription Factors