Combination of Tmprss6- ASO and the iron chelator deferiprone improves erythropoiesis and reduces iron overload in a mouse model of beta-thalassemia intermedia

Haematologica. 2016 Jan;101(1):e8-e11. doi: 10.3324/haematol.2015.133348. Epub 2015 Sep 24.
No abstract available

Keywords: chelator; erythropoiesis; iron metabolism; iron overload; red blood cells.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Deferiprone
  • Disease Models, Animal
  • Erythropoiesis / drug effects*
  • Erythropoiesis / genetics
  • Iron Chelating Agents / pharmacology*
  • Membrane Proteins / antagonists & inhibitors*
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism
  • Mice
  • Pyridones / pharmacology*
  • Serine Endopeptidases / genetics
  • Serine Endopeptidases / metabolism
  • beta-Thalassemia / drug therapy*
  • beta-Thalassemia / genetics
  • beta-Thalassemia / metabolism

Substances

  • Iron Chelating Agents
  • Membrane Proteins
  • Pyridones
  • Deferiprone
  • Serine Endopeptidases
  • matriptase 2