The syndrome of seronegative symmetrical synovitis with pitting edema (RS3 PE syndrome): a unique form of arthritis in the elderly? Report of 4 additional cases

J Rheumatol. 1989 Sep;16(9):1211-3.


We describe 4 elderly patients who presented with peripheral seronegative inflammatory polyarthritis with pitting edema. All of these patients had a spontaneous benign evolution of their disease within 9 to 18 months. None developed erosions or relapse after prolonged followup. This particular pattern of arthritis in elderly patients might represent a separate benign clinical entity among inflammatory arthritis in aging patients.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Aged, 80 and over
  • Arthritis / classification
  • Arthritis / complications*
  • Arthritis, Rheumatoid / complications
  • Edema / complications*
  • Female
  • Humans
  • Male
  • Rheumatoid Factor / analysis
  • Syndrome
  • Synovitis / complications*
  • Synovitis / immunology


  • Rheumatoid Factor