Studies on batch formulation of a kit for the preparation of the 99mTc-Ubiquicidin (29-41): An infection imaging agent

Appl Radiat Isot. 2016 Jan:107:8-12. doi: 10.1016/j.apradiso.2015.09.009. Epub 2015 Sep 11.


The aim of this study was to formulate an indigenous cold kit of Ubiquicidin, UBI (29-41), for easy preparation of (99m)Tc-UBI (29-41) to be used as an infection imaging agent. A two component kit with the peptide and SnCl2 as vial 1 and optimum amount of NaOH as vial 2 was successfully formulated as seen from the consistent radiochemical and pharmaceutical purity of the product over six consecutive batches of kits. The utility of the kit could be demonstrated through in-vitro and in vivo specificity of (99m)Tc-UBI (29-41).

Keywords: (99m)Tc-UBI (29-41); Infection imaging; Kit formulation; Ubiquicidin (29–41).

Publication types

  • Evaluation Study

MeSH terms

  • Animals
  • Chemistry, Pharmaceutical
  • Drug Stability
  • Freeze Drying
  • Humans
  • Infections / diagnostic imaging*
  • Mice
  • Organotechnetium Compounds / isolation & purification*
  • Organotechnetium Compounds / pharmacokinetics
  • Peptide Fragments / isolation & purification*
  • Peptide Fragments / pharmacokinetics
  • Radionuclide Imaging
  • Radiopharmaceuticals / isolation & purification*
  • Radiopharmaceuticals / pharmacokinetics
  • Tissue Distribution


  • Organotechnetium Compounds
  • Peptide Fragments
  • Radiopharmaceuticals
  • technetium 99m ubiquicidin(29-41)