Copper-Catalyzed Carboxylation of Alkenylzirconocenes with Carbon Dioxide Leading to α,β-Unsaturated Carboxylic Acids

Sheng Wang; Peng Shao; Chao Chen; Chanjuan Xi

doi:10.1021/acs.orglett.5b02619

Copper-Catalyzed Carboxylation of Alkenylzirconocenes with Carbon Dioxide Leading to α,β-Unsaturated Carboxylic Acids

Org Lett. 2015 Oct 16;17(20):5112-5. doi: 10.1021/acs.orglett.5b02619. Epub 2015 Sep 25.

Authors

Sheng Wang¹, Peng Shao¹, Chao Chen¹, Chanjuan Xi^{1

2}

Affiliations

¹ Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University , Beijing 100084, China.
² State Key Laboratory of Elemento-Organic Chemistry, Nankai University , Tianjin 300071, China.

PMID: 26406296
DOI: 10.1021/acs.orglett.5b02619

Abstract

A variety of alkenylzirconocenes were efficiently carboxylated by CO2 utilizing the (IMes)CuCl catalyst yielding the corresponding α,β-unsaturated carboxylic acids in good yields. This reaction could be carried out in a one-pot operation via sequential carbozirconation of alkynes and carboxylation using CO2 as starting materials under room temperature.

Publication types

Research Support, Non-U.S. Gov't