No driver behind the wheel? Targeting transcription in cancer

Cell. 2015 Sep 24;163(1):28-30. doi: 10.1016/j.cell.2015.09.013.


Exploiting the dependence of cancer cells on transcription can be used as an effective strategy for targeting aggressive and therapeutically recalcitrant tumors. Wang et al. show that inhibiting transcription using THZ1, a small-molecule inhibitor of cyclin-dependent kinase CDK7, induces apoptotic cell death in triple-negative breast cancers.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cyclin-Dependent Kinases / metabolism*
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Transcription, Genetic*
  • Triple Negative Breast Neoplasms / genetics*


  • Cyclin-Dependent Kinases