Subthreshold Micropulse Laser (577 nm) Treatment in Chronic Central Serous Chorioretinopathy

Ophthalmologica. 2015;234(4):189-94. doi: 10.1159/000439600. Epub 2015 Sep 26.


Purpose: To assess treatment with a 577-nm subthreshold micropulse laser (SML) in patients with chronic central serous chorioretinopathy (cCSC).

Methods: This retrospective study included 38 patients treated with a 577-nm SML (Supra Scan; Quantel Medical) for cCSC. We included a subgroup of 18 patients with persistent subretinal fluid (SRF) after photodynamic therapy (PDT). Assessment included visual acuity (VA), central retinal thickness (CRT) and resolution of SRF.

Results: At the last follow-up (mean 5 months), 74% of patients responded to therapy. The CRT decreased after treatment (mean CRT -115 µm, p < 0.001) and VA improved (mean logMAR -0.06, p = 0.039). No laser burns were detected with any imaging modality. In the subgroup of patients resistant to PDT, 61% of patients responded to therapy with a decrease in CRT (mean CRT -75 µm, p = 0.019).

Conclusions: The 577-nm SML is an effective treatment for cCSC even in patients without sufficient improvement after PDT.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Central Serous Chorioretinopathy / diagnosis
  • Central Serous Chorioretinopathy / drug therapy
  • Central Serous Chorioretinopathy / surgery*
  • Female
  • Fluorescein Angiography
  • Humans
  • Laser Coagulation / methods*
  • Male
  • Middle Aged
  • Photochemotherapy
  • Retina / pathology
  • Retrospective Studies
  • Subretinal Fluid
  • Tomography, Optical Coherence
  • Visual Acuity / physiology