TKTL1 and p63 are biomarkers for the poor prognosis of gastric cancer patients

Cancer Biomark. 2015;15(5):591-7. doi: 10.3233/CBM-150499.


Background: The significance of transketolase-like enzyme 1 (TKTL1) and p63 in the clinical progression and prognosis of gastric cancer patients has not been established.

Objective: This study investigated the expression of TKTL1 and p63 in gastric cancer and their clinical significance.

Methods: TKTL1 and p63 expression in 101 gastric cancer tissue specimens and 25 normal gastric mucosa tissues were detected by immunohistochemistry (IHC).

Results: The percentage of positive TKTL1 and p63 expression in gastric carcinomas was significantly higher than that in normal gastric mucosa tissues (P < 0.05). Positive TKTL1 and p63 expression significantly correlated with larger tumor size, deeper invasion, higher TNM stage, and lymph node metastasis (P< 0.05). The expression of TKTL1 significantly correlated with p63 expression in gastric cancer tissues (r = 0.476, P < 0.01). Univariate analysis revealed that positive TKTL1 and/or positive p63 expression correlated significantly with shorter survival and lower 5-year survival rate (P = 0.001). Cox multivariate analysis demonstrated that expression of TKTL1 and p63 is an independent prognostic factor (P < 0.05) in gastric cancer.

Conclusions: Both TKTL1 and p63 are independent prognostic factors of the poor outcome of gastric cancer patients.

Keywords: TKTL1; gastric cancer; p63; prognosis.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor / biosynthesis*
  • Biomarkers, Tumor / genetics
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Lymphatic Metastasis
  • Male
  • Middle Aged
  • Prognosis
  • Stomach Neoplasms / genetics*
  • Stomach Neoplasms / pathology
  • Transcription Factors / biosynthesis*
  • Transcription Factors / genetics
  • Transketolase / biosynthesis*
  • Transketolase / genetics
  • Tumor Suppressor Proteins / biosynthesis*
  • Tumor Suppressor Proteins / genetics


  • Biomarkers, Tumor
  • TP63 protein, human
  • Transcription Factors
  • Tumor Suppressor Proteins
  • TKTL1 protein, human
  • Transketolase