Chemogenetics-A Transformational and Translational Platform

JAMA Neurol. 2015 Nov;72(11):1361-6. doi: 10.1001/jamaneurol.2015.1921.

Abstract

Neurologic disorders are frequently a result of inappropriate electrical and/or chemical signaling of neurons and glia. Ultimate remediation would necessitate reprogramming these signals. Historically, correcting neuronal and glial signaling is accomplished via drug therapy/administration, although they frequently fail to effectively and fully treat the underlying disorder. Developments in basic research have produced several new classes of potential therapeutics to directly and precisely control neuron activity at the single-cell level. We review one such technology, Designer Receptors Exclusively Activated by Designer Drugs, and suggest its potential as a powerful tool for augmenting neuronal and glial signaling and activity for basic and translational applications.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Brain / drug effects
  • Brain / metabolism*
  • Drug Design*
  • Humans
  • Nervous System Diseases / drug therapy*
  • Neuroglia / metabolism*
  • Neurons / metabolism*
  • Protein Engineering / methods*
  • Receptors, G-Protein-Coupled / genetics
  • Receptors, G-Protein-Coupled / metabolism*
  • Signal Transduction / drug effects*
  • Translational Medical Research / methods

Substances

  • Receptors, G-Protein-Coupled