Caffeoyl glucosides from Nandina domestica inhibit LPS-induced endothelial inflammatory responses

Bioorg Med Chem Lett. 2015 Nov 15;25(22):5367-71. doi: 10.1016/j.bmcl.2015.09.031. Epub 2015 Sep 12.

Abstract

Endothelial dysfunction is a key pathological feature of many inflammatory diseases, including sepsis. In the present study, a new caffeoyl glucoside (1) and two known caffeoylated compounds (2 and 3) were isolated from the fruits of Nandina domestica Thunb. (Berberidaceae). The compounds were investigated for their effects against lipopolysaccharide (LPS)-mediated endothelial inflammatory responses. At 20 μM, 1 and 2 inhibited LPS-induced hyperpermeability, adhesion, and migration of leukocytes across a human endothelial cell monolayer in a dose-dependent manner suggesting that 1 and 2 may serve as potential scaffolds for the development of therapeutic agents to treat vascular inflammatory disorders.

Keywords: Berberidaceae; Caffeoyl glucosides; Nandina domestica Thunb.; Vascular inflammatory disorders.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Berberidaceae / chemistry*
  • Caffeic Acids / chemistry*
  • Caffeic Acids / pharmacology
  • Cell Adhesion / drug effects
  • Cell Movement / drug effects
  • Dose-Response Relationship, Drug
  • Endothelium / drug effects*
  • Endothelium / immunology
  • Fruit / chemistry*
  • Glucosides / chemistry*
  • Glucosides / pharmacology
  • Humans
  • Inflammation / drug therapy
  • Lipopolysaccharides*
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Plant Extracts / chemistry
  • Plant Extracts / pharmacology*

Substances

  • Caffeic Acids
  • Glucosides
  • Lipopolysaccharides
  • Plant Extracts