KCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel regulation

Gene. 2016 Jan 15;576(1 Pt 1):1-13. doi: 10.1016/j.gene.2015.09.059. Epub 2015 Sep 26.

Abstract

The human KCNE gene family comprises five genes encoding single transmembrane-spanning ion channel regulatory subunits. The primary function of KCNE subunits appears to be regulation of voltage-gated potassium (Kv) channels, and the best-understood KCNE complexes are with the KCNQ1 Kv α subunit. Here, we review the often opposite effects of KCNE1 and KCNE3 on Kv channel biology, with an emphasis on regulation of KCNQ1. Slow-activating IKs channel complexes formed by KCNQ1 and KCNE1 are essential for human ventricular myocyte repolarization, while constitutively active KCNQ1-KCNE3 channels are important in the intestine. Inherited sequence variants in human KCNE1 and KCNE3 cause cardiac arrhythmias but by different mechanisms, and each is important for hearing in unique ways. Because of their contrasting effects on KCNQ1 function, KCNE1 and KCNE3 have proved invaluable tools in the mechanistic understanding of how channel gating can be manipulated, and each may also provide a window into novel insights and new therapeutic opportunities in K(+) channel pharmacology. Finally, findings from studies of Kcne1(-/-) and Kcne3(-/-) mouse lines serve to illustrate the complexity of KCNE biology and KCNE-linked disease states.

Keywords: Auditory; Cardiac arrhythmia; Inherited deafness; Intestine; Long QT syndrome; Potassium channel; Voltage-gated.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Arrhythmias, Cardiac* / genetics
  • Arrhythmias, Cardiac* / metabolism
  • Humans
  • Ion Channel Gating / genetics*
  • Mice
  • Mice, Knockout
  • Organ Specificity
  • Potassium Channels, Voltage-Gated* / genetics
  • Potassium Channels, Voltage-Gated* / metabolism

Substances

  • KCNE1 protein, human
  • KCNE3 protein, human
  • Kcne1 protein, mouse
  • Kcne3 protein, mouse
  • Potassium Channels, Voltage-Gated