Long Noncoding RNAs: A New Regulatory Code in Metabolic Control

Trends Biochem Sci. 2015 Oct;40(10):586-596. doi: 10.1016/j.tibs.2015.08.002.


Long noncoding RNAs (lncRNAs) are emerging as an integral part of the regulatory information encoded in the genome. lncRNAs possess the unique capability to interact with nucleic acids and proteins, and exert discrete effects on numerous biological processes. Recent studies have delineated multiple lncRNA pathways that control metabolic tissue development and function. The expansion of the regulatory code that links nutrient and hormonal signals to tissue metabolism gives new insights into the genetic and pathogenic mechanisms underlying metabolic disease. This review discusses lncRNA biology with a focus on their role in the development, signaling, and function of key metabolic tissues.

Keywords: brown fat; energy metabolism; lncRNA; metabolic disease; signaling; transcription.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Energy Metabolism / genetics
  • Energy Metabolism / physiology
  • Humans
  • RNA, Long Noncoding / genetics*
  • RNA, Long Noncoding / physiology*


  • RNA, Long Noncoding