Influence of polyunsaturated fatty acids on urologic inflammation

Int Urol Nephrol. 2015 Nov;47(11):1753-61. doi: 10.1007/s11255-015-1108-8. Epub 2015 Sep 28.


Purpose: Studies demonstrate that polyunsaturated fatty acids, fish oils, and alpha-linoleic acid are beneficial anti-inflammatory agents, which suppress inflammatory mediators and their activity.

Methods: This review focuses on the effects of omega-3 fatty acids (O-3FAs) on three primary urologic organs (bladder, kidney, and prostate) and associated conditions such as urolithiasis, kidney transplantation, interstitial cystitis/bladder pain syndrome, bladder cancer, prostate cancer (CaP), and chronic prostatitis/chronic pelvic pain syndrome.

Results: The following themes emerged: the potential influence of O-3FA in suppressing urologic inflammation; the supportive role of O-3FA in therapeutic interventions; pro-inflammatory mechanisms of omega-6 fatty acids (O-6FAs) associated with disease progression; and the importance of the optimal ratio of O-6FAs/O-3FAs.

Conclusions: The need for further research on the role of PUFAs in suppressing urological inflammation precipitated.

Keywords: Bladder; Inflammation; Kidney; Omega fatty acids; Polyunsaturated fatty acids; Prostate.

Publication types

  • Review

MeSH terms

  • Animals
  • Carcinoma / metabolism
  • Carcinoma / prevention & control
  • Cytokines / blood
  • Fatty Acids, Omega-3 / metabolism
  • Fatty Acids, Omega-3 / therapeutic use*
  • Fatty Acids, Omega-6 / metabolism
  • Humans
  • Inflammation / drug therapy*
  • Inflammation / metabolism
  • Kidney Diseases / drug therapy
  • Kidney Transplantation
  • Male
  • Prostatic Diseases / drug therapy
  • Prostatic Neoplasms / metabolism
  • Prostatic Neoplasms / prevention & control
  • Prostatitis / blood
  • Urinary Bladder Diseases / drug therapy
  • Urologic Diseases / drug therapy*
  • Urologic Diseases / metabolism
  • Urologic Diseases / prevention & control


  • Cytokines
  • Fatty Acids, Omega-3
  • Fatty Acids, Omega-6