Primary signet ring cell carcinoma of the colon and rectum

Samia Arifi; Omar Elmesbahi; Afaf Amarti Riffi

doi:10.1016/j.bulcan.2015.07.005

Primary signet ring cell carcinoma of the colon and rectum

Bull Cancer. 2015 Oct;102(10):880-8. doi: 10.1016/j.bulcan.2015.07.005. Epub 2015 Sep 26.

Authors

Samia Arifi¹, Omar Elmesbahi², Afaf Amarti Riffi³

Affiliations

¹ Hassan II university Hospital, Sidi Mohamed ben Abdullah University, School of medicine, Medical oncology department, Fez, Morocco; Hassan II university hospital, Mohamed ben Abdullah University, School of medicine, Laboratory of cancer biology, Fez, Morocco. Electronic address: drsarifi@yahoo.fr.
² Hassan II university Hospital, Sidi Mohamed ben Abdullah University, School of medicine, Medical oncology department, Fez, Morocco.
³ Hassan II university hospital, Mohamed ben Abdullah University, School of medicine, Laboratory of cancer biology, Fez, Morocco; Hassan II university Hospital, Mohamed ben Abdullah University, School of medicine, Pathology department, Fez, Morocco; Laboratory of pathology Al Azhar, Fez, Morocco.

PMID: 26412710
DOI: 10.1016/j.bulcan.2015.07.005

Abstract

Colorectal primary signet ring cell carcinoma (SRCC) is a rare entity accounting for nearly 1% of all colorectal carcinomas. It is an independent prognostic factor associated with less favorable outcome. This aggressiveness is mainly due to the intrinsic biology of these tumors. Here is an overview of the literature related to clinicopathological features, molecular biology, and management of SRCC of the colon and the rectum.

Keywords: Colorectal cancer; Molecular biology; Pathology; Signet ring cell; Treatment.

Publication types

Review

MeSH terms

Carcinoma, Signet Ring Cell* / epidemiology
Carcinoma, Signet Ring Cell* / genetics
Carcinoma, Signet Ring Cell* / pathology
Carcinoma, Signet Ring Cell* / therapy
Colonic Neoplasms* / epidemiology
Colonic Neoplasms* / genetics
Colonic Neoplasms* / pathology
Colonic Neoplasms* / therapy
Genes, ras
Humans
Incidence
Loss of Heterozygosity
Microsatellite Instability
Mucin 5AC / metabolism
Mucin-2 / metabolism
Mutation
Neoplasm Proteins / metabolism
Prognosis
Rare Diseases* / epidemiology
Rare Diseases* / genetics
Rare Diseases* / pathology
Rare Diseases* / therapy
Rectal Neoplasms* / epidemiology
Rectal Neoplasms* / genetics
Rectal Neoplasms* / pathology
Rectal Neoplasms* / therapy
raf Kinases / genetics

Substances

MUC2 protein, human
MUC5AC protein, human
Mucin 5AC
Mucin-2
Neoplasm Proteins
raf Kinases