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. 2015 Apr;2015:1402-1406.
doi: 10.1109/ISBI.2015.7164138.

Medial Demons Registration Localizes The Degree of Genetic Influence Over Subcortical Shape Variability: An N= 1480 Meta-Analysis

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Free PMC article

Medial Demons Registration Localizes The Degree of Genetic Influence Over Subcortical Shape Variability: An N= 1480 Meta-Analysis

Boris A Gutman et al. Proc IEEE Int Symp Biomed Imaging. .
Free PMC article

Abstract

We present a multi-cohort shape heritability study, extending the fast spherical demons registration to subcortical shapes via medial modeling. A multi-channel demons registration based on vector spherical harmonics is applied to medial and curvature features, while controlling for metric distortion. We registered and compared seven subcortical structures of 1480 twins and siblings from the Queensland Twin Imaging Study and Human Connectome Project: Thalamus, Caudate, Putamen, Pallidum, Hippocampus, Amygdala, and Nucleus Accumbens. Radial distance and tensor-based morphometry (TBM) features were found to be highly heritable throughout the entire basal ganglia and limbic system. Surface maps reveal subtle variation in heritability across functionally distinct parts of each structure. Medial Demons reveals more significantly heritable regions than two previously described surface registration methods. This approach may help to prioritize features and measures for genome-wide association studies.

Keywords: heritability; medial curves; meta-analysis; shape registration; spherical demons.

Figures

Figure 1
Figure 1
Mapping a subcortical structure to a template by matching spherical curvature maps.
Figure 2
Figure 2
(a) Medial curve of a left lateral ventricular surface; (b) The resulting global orientation function.
Figure 3
Figure 3. Lower bound of heritability for the Log Jacobian
Figure 4
Figure 4. Lower bound of heritability for Radial Distance
Figure 5
Figure 5
(A) and (B): lateral and medial views of corrected Log p-values after Medial Demons; (C) and (D): corresponding results after conformal registration. Left: Caudate; Right: Thalamus

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