Clinical translation of a high-performance neural prosthesis

Vikash Gilja; Chethan Pandarinath; Christine H Blabe; Paul Nuyujukian; John D Simeral; Anish A Sarma; Brittany L Sorice; János A Perge; Beata Jarosiewicz; Leigh R Hochberg; Krishna V Shenoy; Jaimie M Henderson

doi:10.1038/nm.3953

Clinical translation of a high-performance neural prosthesis

Nat Med. 2015 Oct;21(10):1142-5. doi: 10.1038/nm.3953. Epub 2015 Sep 28.

Authors

Vikash Gilja^{1

2

3

4}, Chethan Pandarinath^{1

2

5}, Christine H Blabe¹, Paul Nuyujukian^{1

2

5}, John D Simeral^{3

6

7

8}, Anish A Sarma^{3

6

7

8}, Brittany L Sorice⁸, János A Perge^{3

6

7}, Beata Jarosiewicz^{6

7

9}, Leigh R Hochberg^{3

6

7

8

10}, Krishna V Shenoy^{2

5

11

12

13}, Jaimie M Henderson^{1

5}

Affiliations

¹ Department of Neurosurgery, Stanford University, Stanford, California, USA.
² Department of Electrical Engineering, Stanford University, Stanford, California, USA.
³ School of Engineering, Brown University, Providence, Rhode Island, USA.
⁴ Department of Electrical and Computer Engineering, University of CaliforniaSan Diego, La Jolla, California, USA.
⁵ Stanford Neurosciences Institute, Stanford University, Stanford, California, USA.
⁶ Center for Neurorestoration and Neurotechnology, Rehabilitation R&D Service, Department of Veterans Affairs Medical Center, Providence, Rhode Island, USA.
⁷ Brown Institute for Brain Science, Brown University, Providence, Rhode Island, USA.
⁸ Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.
⁹ Department of Neuroscience, Brown University, Providence, Rhode Island, USA.
¹⁰ Neurology, Harvard Medical School, Boston,Massachusetts, USA.
¹¹ Department of Neurobiology, Stanford University, Stanford, California, USA.
¹² Department of Bioengineering, Stanford University, Stanford, California, USA.
¹³ Howard Hughes Medical Institute, Stanford University, Stanford, California, USA.

PMID: 26413781
PMCID: PMC4805425
DOI: 10.1038/nm.3953

Abstract

Neural prostheses have the potential to improve the quality of life of individuals with paralysis by directly mapping neural activity to limb- and computer-control signals. We translated a neural prosthetic system previously developed in animal model studies for use by two individuals with amyotrophic lateral sclerosis who had intracortical microelectrode arrays placed in motor cortex. Measured more than 1 year after implant, the neural cursor-control system showed the highest published performance achieved by a person to date, more than double that of previous pilot clinical trial participants.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Humans
Microelectrodes
Neural Prostheses*
Paralysis / therapy*
Quality of Life
Translational Research, Biomedical*

Abstract

Publication types

MeSH terms

Grants and funding