A positive-negative mode of population covariation links brain connectivity, demographics and behavior

Nat Neurosci. 2015 Nov;18(11):1565-7. doi: 10.1038/nn.4125. Epub 2015 Sep 28.


We investigated the relationship between individual subjects' functional connectomes and 280 behavioral and demographic measures in a single holistic multivariate analysis relating imaging to non-imaging data from 461 subjects in the Human Connectome Project. We identified one strong mode of population co-variation: subjects were predominantly spread along a single 'positive-negative' axis linking lifestyle, demographic and psychometric measures to each other and to a specific pattern of brain connectivity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Behavior / physiology*
  • Brain / cytology*
  • Brain / physiology
  • Cluster Analysis
  • Connectome / methods
  • Demography* / methods
  • Female
  • Humans
  • Magnetic Resonance Imaging / methods
  • Male
  • Models, Neurological*
  • Nerve Net / cytology*
  • Nerve Net / physiology
  • Young Adult