Objective: To evaluate the influence of µl-opioid receptor (OPRM1) 118A>G and catechol-O-methyltransferase (COMT) 1947G>A gene single nucleotide polymorphisms (SNP) combinations on postoperative opioid analgesia (POA) efficacy.
Material and methods: In 100 consecutive patients scheduled for major urologic surgeries the SNPs of OPRM1 118A>G and COMT 1947G>A (real-time PCR), preoperative anxiety and depression level (HADS scale), POA efficacy ("Pain Out" questionnaire) have been assessed.
Results: Preoperative anxiety and depression, additional analgesia requirements, severity of nausea, drowsiness and incidence of vomiting were higher in OPRM1 118G allele carriers. Maximum pain intensity and pain-related restriction of mobility on first postoperative day were lower in homozygous carriers of COMT 1947A. The best response to POA in view of preoperative anxiety, analgesia efficacy and severity of nausea has been revealed in carriers of combination COMT-OPRM1 AA-AA.
Conclusions: SNPs of OPRM1 118A>G and COMT 1947G>A affect the preoperative patients psychological status and POA efficacy.