Allergen immunotherapy on the way to product-based evaluation-a WAO statement

Claus Bachert; Mark Larché; Sergio Bonini; Giorgio Walter Canonica; Thomas Kündig; Desiree Larenas-Linnemann; Dennis Ledford; Hugo Neffen; Ruby Pawankar; Giovanni Passalacqua

doi:10.1186/s40413-015-0078-8

Allergen immunotherapy on the way to product-based evaluation-a WAO statement

World Allergy Organ J. 2015 Sep 16;8(1):29. doi: 10.1186/s40413-015-0078-8. eCollection 2015.

Authors

Affiliations

¹ Upper Airway Research Laboratory, University of Ghent, Ghent, Belgium.
² Firestone Institute for Respiratory Health, Department of Medicine, St. Joseph's Hospital Healthcare, McMaster University, Hamilton, Canada.
³ Second University of Naples, Rome, Italy.
⁴ Allergy and Respiratory Diseases, DIMI Department of Internal Medicine, University of Genova, IRCCS AOU S. Martino, Genova, Italy.
⁵ Department of Dermatology, University Hospital Zurich, Zürich, Switzerland.
⁶ Hospital Medica Sur, Toriello Guerra, Delegacion Tlalpan, Mexico, DF Mexico.
⁷ Morsani College of Medicine, University of South Florida, Tampa, Florida USA.
⁸ Head, Respiratory Medicine Unit, Orlando Alassia Hospital, Santa Fe, Argentina.
⁹ Division of Allergy, Department of Pediatrics, Nippon Medical School, Tokyo, Japan.

Abstract

Allergen immunotherapy (AIT) is widely used in clinical practice for patients with moderate to severe allergic rhinitis due to inhalant allergens and may be delivered via subcutaneous (SCIT) and sublingual routes (SLIT). However, the quality of evidence for individual AIT products is very heterogeneous, and extensions of overall conclusions ("class effects") on the efficacy and disease-modifying effects to all AIT products are unjustified. In contrast, each product needs to be evaluated individually, based on available study results, to justify efficacy and specific claims on sustained and disease modifying effects per allergen and targeted patient group (children vs. adults, allergic rhinitis vs. asthma). WAO intends to support the current development to evidence-based AIT, which ultimately will lead to a more efficacious treatment of allergic patients and the appropriate recognition of AIT.