TREATMENT OF PERSISTENTLY OPEN MACULAR HOLES WITH HEAVY SILICONE OIL (DENSIRON 68) VERSUS C2F6. A PROSPECTIVE RANDOMIZED STUDY

Retina. 2016 Apr;36(4):688-94. doi: 10.1097/IAE.0000000000000781.

Abstract

Purpose: To compare the efficacy of a mixture of silicone oil and perfluorohexyloctane (Densiron 68) with C2F6 gas endotamponade in the retreatment of persistently open full-thickness macular holes.

Methods: In this prospective randomized study, 21 consecutive patients who were unsuccessfully operated on for large idiopathic full-thickness macular hole were randomly assigned to undergo a second vitrectomy with 20% perfluoroethane gas (C2F6, Group A) or with Densiron 68 tamponade (Group B).

Primary outcomes: Endpoint (12 months) full-thickness macular hole closure rate by spectral domain optical coherence tomography and logMAR corrected distance visual acuity.

Secondary outcomes: postoperative adverse events.

Results: The mean diameter of macular holes before the second pars plana vitrectomy was 680.3 ± 120.8 μm and 740.5 ± 105.3 μm in Groups A and B, respectively (P = 0.237); mean preoperative corrected distance visual acuity was 0.96 ± 0.36 logMAR and 1.12 ± 0.35 logMAR, respectively (P = 0.315). Endpoint full-thickness macular hole closure was obtained in 30% of patients (3/10) in Group A and in 82% (9/11) in Group B (P = 0.030). Corrected distance visual acuities were, respectively, 0.80 ± 0.25 logMAR and 0.55 ± 0.20 logMAR, with significant intergroup difference (P = 0.019); corrected distance visual acuity increased in Group B only (P = 0.003). No differences in complications were found.

Conclusion: The results indicate that Densiron 68 tamponade could be a useful, safe, and more efficacious method than gas tamponade to retreat persisting macular holes.

Publication types

  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Aged
  • Aged, 80 and over
  • Endotamponade*
  • Female
  • Fluorocarbons / administration & dosage*
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Reoperation
  • Retinal Perforations / diagnosis
  • Retinal Perforations / physiopathology
  • Retinal Perforations / therapy*
  • Silicone Oils / administration & dosage*
  • Tomography, Optical Coherence
  • Visual Acuity / physiology
  • Vitrectomy*

Substances

  • Fluorocarbons
  • Silicone Oils
  • densiron-68
  • perfluoroethane