The discovery of modular binding domains: building blocks of cell signalling

Nat Rev Mol Cell Biol. 2015 Nov;16(11):691-8. doi: 10.1038/nrm4068. Epub 2015 Sep 30.


Cell signalling - the ability of a cell to process information from the environment and change its behaviour in response - is a central property of life. Signalling depends on proteins that are assembled from a toolkit of modular domains, each of which confers a specific activity or function. The discovery of modular protein- and lipid-binding domains was a crucial turning point in understanding the logic and evolution of signalling mechanisms.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Cells / metabolism*
  • Evolution, Molecular
  • Humans
  • Lipid Metabolism*
  • Protein Binding
  • Proteins / chemistry*
  • Signal Transduction*
  • src Homology Domains*


  • Proteins