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Clinical Course and Complications Following Diagnostic Bronchoalveolar Lavage in Critically Ill Mechanically Ventilated Patients


Clinical Course and Complications Following Diagnostic Bronchoalveolar Lavage in Critically Ill Mechanically Ventilated Patients

R M Schnabel et al. BMC Pulm Med.


Background: Flexible, fibreoptic bronchoscopy (FFB) and bronchoalveolar lavage (BAL) have been used for diagnostic purposes in critically ill ventilated patients. The additional diagnostic value compared to tracheal aspirations in ventilator-associated pneumonia (VAP) has been questioned. Nevertheless, BAL can provide extra information for the differential diagnosis of respiratory disease and good antibiotic stewardship. These benefits should outweigh potential hazards caused by the invasiveness of this diagnostic technique. The focus of the present study was on the clinical course and complications of patients following BAL procedures up to 24 h.

Methods: Hundred sixty-four FFB guided BAL procedures for suspected pneumonia were analysed in an observational study. The clinical course of patients was monitored by respiratory and haemodynamic data before BAL, 1 and 24 h after BAL. Complications were defined and registered. Factors associated with complications were analysed by logistic regression.

Clinical course: a decrease in average pO2/FiO2 ratio 1 h after BAL from 29 kPa (218 mmHg) to 25 kPa (189 mmHg) (p < 0.05) was observed which fully recovered within 24 h. Respiratory complications: the incidence of procedure related hypo-oxygenation (SaO2 ≤ 88 %) and/or bronchospasm was 9 %; a decrease of >25 % PaO2/FiO2 ratio 1 h after BAL was found in 29 % of patients; no bleeding or pneumothorax were registered. Haemodynamic complications: there were no cases of hypertension and cardiac rhythm disturbances; haemodynamic instability within the first 24 h after BAL was recorded in 22 %; this was correlated with a cardiovascular diagnosis at admission (OR 2.9; 95 % CI 1.2 - 6.7) and the presence of cardiovascular co-morbidity (OR 3.5; 95 % CI 1.5 - 8.3). The incidence of bacteraemia was 7 %. There was no case of procedure related death.

Discussion: Frequently occurring haemodynamic and respiratory instability but no cases of cardiac rhythm disturbances, bleeding, pneumothorax or procedure related death were attributable to diagnostic FFB and BAL. The procedures should be conducted under careful supervision by experienced physicians. Only a randomized controlled trial that compares diagnostic FFB and BAL with a non-invasive strategy could ultimately establish the safety profile and clinical utility of these procedures in critically ill ventilated patients.


Fig. 1
Fig. 1
Results – Odds ratios and 95 % confidence interval for respiratory complications1 of BAL. 1 Decrease of the PaO2/FiO2 > 25 % compared to baseline within 1 h after BAL
Fig. 2
Fig. 2
Results – Odds ratios with 95 % confidence interval for hemodynamic complications 1 of BAL. A cardiovascular diagnosis upon admission and cardiovascular co-morbidity are associated with significantly more hemodynamic complications. 1Decrease of mean arterial pressure (MAP) < 55 mmHg at any time and/or necessity to initiate norepinephrine > 0.15 μg/kg/min / dubutamine >5 μg/kg/min and/or the necessity to more than double the dose of norepinephrine or dobutamine

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Cited by 4 PubMed Central articles


    1. Fagon JY, Chastre J, Wolff M, Gervais C, Parer-Aubas S, Stephan F, et al. Invasive and noninvasive strategies for management of suspected ventilator-associated pneumonia. A randomized trial. Ann Intern Med. 2000;132:621–30. doi: 10.7326/0003-4819-132-8-200004180-00004. - DOI - PubMed
    1. Shorr AF, Sherner JH, Jackson WL, Kollef MH. Invasive approaches to the diagnosis of ventilator-associated pneumonia: a meta-analysis. Crit Care Med. 2005;33:46–53. doi: 10.1097/01.CCM.0000149852.32599.31. - DOI - PubMed
    1. Fagon JY. Diagnosis and treatment of ventilator-associated pneumonia: fiberoptic bronchoscopy with bronchoalveolar lavage is essential. Semin Respir Crit Care Med. 2006;27:34–44. doi: 10.1055/s-2006-933672. - DOI - PubMed
    1. Canadian Critical Care Trials, G A randomized trial of diagnostic techniques for ventilator-associated pneumonia. N Engl J Med. 2006;355:2619–30. doi: 10.1056/NEJMoa052904. - DOI - PubMed
    1. Berton DC, Kalil AC, Teixeira PJ. Quantitative versus qualitative cultures of respiratory secretions for clinical outcomes in patients with ventilator-associated pneumonia. Cochrane Database Syst Rev. 2014;10:CD006482. - PubMed

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