A lncRNA to repair DNA

EMBO Rep. 2015 Nov;16(11):1413-4. doi: 10.15252/embr.201541309. Epub 2015 Sep 29.

Abstract

Long non-coding RNAs (lncRNAs) have emerged as regulators of various biological processes, but to which extent lncRNAs play a role in genome integrity maintenance is not well understood. In this issue of EMBO Reports, Sharma et al [1] identify the DNA damage-induced lncRNA DDSR1 as an integral player of the DNA damage response (DDR). DDSR1 has both an early role by modulating repair pathway choices, and a later function when it regulates gene expression. Sharma et al [1] thus uncover a dual role for a hitherto uncharacterized lncRNA during the cellular response to DNA damage.

Publication types

  • Comment

MeSH terms

  • BRCA1 Protein / metabolism*
  • DNA Damage*
  • Homologous Recombination*
  • Humans
  • RNA, Long Noncoding / genetics*
  • RNA, Long Noncoding / metabolism*

Substances

  • BRCA1 Protein
  • RNA, Long Noncoding