Neurological complications of sarcoidosis

Clin Exp Neurol. 1989;26:99-112.


The medical records of 285 patients at Royal Prince Alfred Hospital with a definite diagnosis of sarcoidosis over the period 1973-87 were reviewed. Fourteen (4.9%) had involvement of the nervous system, in 8 of whom the neurological manifestations were the presenting feature of the disease. The age range of neurosarcoidosis was 22 to 79 years and there was a female preponderance (10:4). Neurological complications (some patients experienced more than one complication) were facial nerve palsy (4), myopathy (3), aseptic meningitis (3), deafness/vertigo (2), hydrocephalus (2), hypopituitarism (2) and peripheral neuropathy (1). Most patients received corticosteroid therapy. Two patients required neurosurgical management for hydrocephalus and 1 for pituitary sarcoid. The frequency and type of neurological complications in this Australian study are similar to those reported from the Northern Hemisphere.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Australia
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nervous System Diseases / diagnosis
  • Nervous System Diseases / etiology*
  • Nervous System Diseases / physiopathology
  • Sarcoidosis / complications*